Owner Isis Pharmaceuticals, Inc.

Inventors Swayze, Eric E.; Bhanot, Sanjay; Seth, Punit P.; McKay, Robert; Geary, Richard S.; Wancewicz, Edward; Siwkowski, Andrew M.; Monia, Brett P.

Agent Pizzeys

Pub. Number AU-B-2007257094

PCT Pub. Number WO2007/143316

Priority PCT/ US2007/061183 27.01.07 US; 60/746,631 05.05.06 US; 60/805,660 23.06.06 US; 60/864,554 06.11.06 US; 60/747,059 11.05.06 US

Filing date 7 May 2007

Wipo publication date 13 December 2007

Acceptance publication date 25 October 2012

A61K 31/70 - Carbohydrates

A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 43/00 Drugs for specific purposes, not provided for in groups

C07H 21/02 Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07H 21/04 Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C12N 15/113 Mutation or genetic engineering - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

C12Q 1/68 Measuring or testing processes involving enzymes or micro-organisms - involving nucleic acids