Owner ISIS PHARMACEUTICALS, INC.

Inventors Seth, Punit P.; Monia, Brett P.; Wancewicz, Edward; McKay, Robert; Geary, Richard S.; Swayze, Eric E.; Bhanot, Sanjay; Siwkowski, Andrew M.

Agent A J Park

Pub. Number AU-A-2007257093

PCT Pub. Number WO2007/143315

Priority 60/747,059 11.05.06 US; 60/805,660 23.06.06 US; 60/864,554 06.11.06 US; PCT/ US2007/061183 27.01.07 US; 60/746,631 05.05.06 US

Filing date 7 May 2007

Wipo publication date 13 December 2007

A61K 31/70 (2006.01) - Carbohydrates

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 43/00 (2006.01) Drugs for specific purposes, not provided for in groups

C07H 21/02 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07H 21/04 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C12N 15/87 (2006.01) Mutation or genetic engineering - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

C12Q 1/68 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving nucleic acids