Owner Pharmacopeia, LLC Schering Corporation

Inventors Taveras, Arthur G.; Aki, Cynthia J.; Bond, Richard W.; Chao, Jianping; Dwyer, Michael; Ferreira, Johan A.; Chao, Jianhua; Yu, Younong; Baldwin, John J.; Kaiser, Bernd; Li, Ge; Merritt, J. Robert; Nelson, Kingsley H.; Rokosz, Laura L.

Agent Griffith Hack

Pub. Number AU-B-2010212484

Parent 2006203679

Filing date 20 August 2010

Wipo publication date 9 September 2010

Acceptance publication date 12 April 2012

C07C 237/30 (2006.01) Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by amino groups

A61K 31/166 (2006.01) - having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol

A61K 31/167 (2006.01) - having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

A61K 31/341 (2006.01) - not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine

A61K 31/343 (2006.01) - condensed with a carbocyclic ring, e.g. coumaran, bufuralol, befunolol, clobenfurol, amiodarone

A61K 31/36 (2006.01)

A61K 31/381 (2006.01) - having five-membered rings

A61K 31/397 (2006.01) - having four-membered rings, e.g. azetidine

A61K 31/40 (2006.01) - having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

A61K 31/401 (2006.01) - Proline

A61K 31/41 (2006.01) - having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole

A61K 31/415 (2006.01) - 1,2-Diazoles

A61K 31/416 (2006.01) - condensed with carbocyclic ring systems, e.g. indazole

A61K 31/4192 (2006.01) - 1,2,3-Triazoles

A61K 31/42 (2006.01) - Oxazoles

A61K 31/4245 (2006.01) - Oxadiazoles

A61K 31/433 (2006.01) - Thiadiazoles

A61K 31/4402 (2006.01) - only substituted in position 2, e.g. pheniramine, bisacodyl

A61K 31/4406 (2006.01) - only substituted in position 3, e.g. zimeldine

A61K 31/4409 (2006.01) - only substituted in position 4, e.g. isoniazid, iproniazid

A61K 31/443 (2006.01)

A61K 31/445 (2006.01) - Non-condensed piperidines, e.g. piperocaine

A61K 31/495 - having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine