Owner Isis Pharmaceuticals, Inc.

Inventors Crooke, Stanely T.; Baker, Brenda; Eldrup, Anne B.; Manoharan, Muthiah; Bhat, Balkrishen; Griffey, Richard; Swayze, Eric E.; Prakash, Thazha P.

Agent Pizzeys

Pub. Number AU-B-2010201712

Parent 2003295388

Filing date 29 April 2010

Wipo publication date 20 May 2010

Acceptance publication date 31 May 2012

C12N 15/11 (2006.01) Mutation or genetic engineering - DNA or RNA fragments

A01N 43/04 (2006.01) Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

C07H 21/00 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07H 21/02 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07H 21/04 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C12N 15/113 (2010.01) Mutation or genetic engineering - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

C12P 19/34 (2006.01) Preparation of compounds containing saccharide radicals

C12Q 1/68 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving nucleic acids