Enhancement of siRNA silencing activity using universal bases or mismatches in the sense strand

Details for Australian Patent Application No. 2009273878 (hide)

Owner Alnylam Pharmaceuticals, Inc.

Inventors Maier, Martin; Addepalli, Haripriya; Manoharan, Muthiah

Agent Griffith Hack

Pub. Number AU-A-2009273878

PCT Pub. Number WO2010/011895

Priority 61/083,763 25.07.08 US

Filing date 24 July 2009

Wipo publication date 28 January 2010

International Classifications

A61K 31/713 (2006.01) - Double-stranded nucleic acids or oligonucleotides

C07H 21/00 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C12N 15/11 (2006.01) Mutation or genetic engineering - DNA or RNA fragments

Event Publications

24 February 2011 PCT application entered the National Phase

  PCT publication WO2010/011895 Priority application(s): WO2010/011895

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