Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components

Details for Australian Patent Application No. 2009234266 (hide)

Owner Alnylam Pharmaceuticals, Inc.

Inventors Butler, David; Manoharan, Muthiah; Rajeev, Kallanthottathil G.; Matsuda, Shigeo; Jayaraman, Muthusamy; Narayanannair, Jayaprakash K.

Agent Griffith Hack

Pub. Number AU-A-2009234266

PCT Pub. Number WO2009/126933

Priority 61/044,186 11.04.08 US

Filing date 10 April 2009

Wipo publication date 15 October 2009

International Classifications

A61K 31/713 (2006.01) - Double-stranded nucleic acids or oligonucleotides

A61K 47/48 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

C07H 21/00 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

Event Publications

2 December 2010 PCT application entered the National Phase

  PCT publication WO2009/126933 Priority application(s): WO2009/126933

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