Owner Astellas Pharma Inc. Juridical Foundation The Chemo-Sero-Therapeutic Research Institute

Inventors Fujita, Hirotada; Ishikawa, Daisuke; Higuchi, Hirofumi; Sakai, Fumihiko; Uehara, Kenji; Nakashima, Toshihiro; Yamamoto, Nobuchika

Agent Davies Collison Cave

Pub. Number AU-A-2009203369

PCT Pub. Number WO2009/088064

Priority 2008-004975 11.01.08 JP; 2008-282496 31.10.08 JP

Filing date 9 January 2009

Wipo publication date 16 July 2009

C12N 15/00 (2006.01) Mutation or genetic engineering

A61K 39/395 (2006.01) Medicinal preparations containing antigens or antibodies - Antibodies

A61P 29/00 (2006.01) Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

C07K 16/28 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C07K 16/46 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies - Hybrid immunoglobulins

C12N 1/15 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 1/19 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 1/21 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 5/10 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

C12P 21/08 (2006.01) Preparation of peptides or proteins - Monoclonal antibodies