Owner Japan Tobacco Inc.

Inventors Tsutsumi, Kazuhiro; Ueno, Hiroshi; Sasaki, Shin-Ya; Shimada, Takashi; Katoh, Susumu; Manabe, Tomoyuki; Aoyagi, Kouichi

Agent Phillips Ormonde Fitzpatrick

Pub. Number AU-A-2008314933

PCT Pub. Number WO2009/054479

Priority 61/001,823 05.11.07 US; 2007-279697 26.10.07 JP

Filing date 24 October 2008

Wipo publication date 30 April 2009

C07C 59/72 (2006.01) Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, CHO, keto, ether, groups, groups, or groups

A61K 31/41 (2006.01) - having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole

A61K 31/421 (2006.01) - 1,3-Oxazoles, e.g. pemoline, trimethadione

A61K 31/426 (2006.01) - 1,3-Thiazoles

A61K 31/44 (2006.01) - Non-condensed pyridines

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

A61P 43/00 (2006.01) Drugs for specific purposes, not provided for in groups

C07C 235/34 (2006.01) Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms

C07D 213/64 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 257/04 (2006.01) Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms

C07D 263/32 (2006.01) Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings

C07D 277/20 (2006.01) Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings

C07D 277/34 (2006.01) Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings