4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5h-pyrimido [4, 5-B[1, 4] diazepin2-ylamino)-3-methoxybenzamide derivatives as inhibitors of the human protein kinases PLK1 to PLK4 for the treatment of proliferative diseases

Details for Australian Patent Application No. 2008287339 (hide)

Owner Vertex Pharmaceuticals Incorporated

Inventors Charrier, Jean-Damien; Pierard, Francoise

Agent Spruson & Ferguson

Pub. Number AU-A-2008287339

PCT Pub. Number WO2009/023269

Priority 60/964,825 15.08.07 US; 60/980,629 17.10.07 US

Filing date 15 August 2008

Wipo publication date 19 February 2009

International Classifications

C07D 487/04 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups

A61K 31/551 (2006.01) - having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep

A61P 25/28 (2006.01) Drugs for disorders of the nervous system

A61P 35/00 (2006.01) Antineoplastic agents

A61P 37/00 (2006.01) Drugs for immunological or allergic disorders

Event Publications

4 March 2010 PCT application entered the National Phase

  PCT publication WO2009/023269 Priority application(s): WO2009/023269

17 June 2010 Amendment Made

  The nature of the amendment is: Amend the invention title to read 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b[1, 4] diazepin2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases

15 July 2010 Corrigenda

  Amendments - Amendments Made Under the name Vertex Pharmaceuticals Incorporated, Application No. 2008287339, under INID (54), correct the invention title to 4-(9-(3, 3-difluorocyclopentyl) -5, 7, 7-trimethyl-6-oxo-6, 7, 8, 9-tetrahydro-5H-pyrimido [4, 5-b][1, 4] diazepin2-ylamino)-3-methoxybenzamide Derivatives as Inhibitors of the Human Protein Kinases PLK1 to PLK4 for the Treatment of Proliferative Diseases

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