Owner F. Hoffmann-La Roche AG

Inventors Adam, Jean-Michael; Binggeli, Alfred; Schmid, Rudolf; Green, Luke; Hartmann, Guido; Wirz, Beat; Mattei, Patrizio; Maerki, Hans P.; Iding, Hans; Ricklin, Fabienne; Aebi, Johannes

Agent Spruson & Ferguson

Pub. Number AU-A-2008277796

PCT Pub. Number WO2009/010429

Priority 07112766.6 19.07.07 EP

Filing date 9 July 2008

Wipo publication date 22 January 2009

C07D 241/08 (2006.01) Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings

A61K 31/495 (2006.01) - having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

A61K 31/496 (2006.01) - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene

A61P 9/10 (2006.01) Drugs for disorders of the cardiovascular system

C07D 285/18 (2006.01) Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups

C07D 401/06 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 403/06 (2006.01) Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group