Owner Isis Pharmaceuticals, Inc.

Inventors Crooke, Rosanne M.; Graham, Mark J.

Agent Pizzeys

Pub. Number AU-B-2008213712

Parent 2002355552

Filing date 11 September 2008

Wipo publication date 2 October 2008

Acceptance publication date 13 September 2012

C12N 15/09 Mutation or genetic engineering - Recombinant DNA-technology

A61K 31/7088 - Compounds having three or more nucleosides or nucleotides

A61K 31/7115 - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine

A61K 31/712 - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose

A61K 31/7125 - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters

A61K 48/00 Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 3/06 Drugs for disorders of the metabolism

A61P 9/00 Drugs for disorders of the cardiovascular system

A61P 9/10 Drugs for disorders of the cardiovascular system

C12N 15/113 Mutation or genetic engineering - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides

A61K 38/00 Medicinal preparations containing peptides