Owner Amgen Inc.

Inventors Ma, Zhihua; Houze, Jonathan B.; Pattaropong, Vatee; Liu, Jiwen; Sharma, Rajiv; Medina, Julio C.; Schmitt, Michael J.; Wang, Yingcai; Liu, Jinqian; Dransfield, Paul; Brown, Sean P.

Agent Shelston IP

Pub. Number AU-B-2007292816

PCT Pub. Number WO2008/030618

Priority 60/843,262 07.09.06 US

Filing date 6 September 2007

Wipo publication date 13 March 2008

Acceptance publication date 17 November 2011

C07D 213/55 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

A61K 31/192 (2006.01)

A61K 31/40 (2006.01) - having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

A61P 3/04 (2006.01) Drugs for disorders of the metabolism

A61P 3/06 (2006.01) Drugs for disorders of the metabolism

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

A61P 7/02 (2006.01) Drugs for disorders of the blood or the extracellular fluid

A61P 9/10 (2006.01) Drugs for disorders of the cardiovascular system

A61P 13/12 (2006.01) Drugs for disorders of the urinary system

A61P 15/00 (2006.01) Drugs for genital or sexual disorders

A61P 35/00 (2006.01) Antineoplastic agents

C07C 59/72 (2006.01) Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, CHO, keto, ether, groups, groups, or groups

C07C 233/65 (2006.01) Carboxylic acid amides

C07D 207/327 (2006.01) Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D 231/12 (2006.01) Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings

C07D 233/64 (2006.01) Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings

C07D 239/26 (2006.01) Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D 249/10 (2006.01) Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms

C07D 257/04 (2006.01) Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms

C07D 261/08 (2006.01) Heterocyclic compounds having nitrogen and oxygen as the only ring hetero atoms

C07D 263/32 (2006.01) Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings

C07D 277/587 (2006.01) Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings

C07D 285/12 (2006.01) Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups