Owner Amgen Inc.

Inventors Kaizerman, Jacob; Wang, Zhulun; Powers, Jay P.; Sun, Daqing; Julian, Lisa; Rew, Yosup; Degraffenreid, Michael; Yan, Xuelei; Mcminn, Dustin

Agent Shelston IP

Pub. Number AU-B-2007259144

PCT Pub. Number WO2007/145835

Priority 60/811,758 08.06.06 US; 60/879,539 10.01.07 US

Filing date 31 May 2007

Wipo publication date 21 December 2007

Acceptance publication date 19 April 2012

C07C 235/54 (2006.01) Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms

A61K 31/166 (2006.01) - having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol

A61K 31/381 (2006.01) - having five-membered rings

A61K 31/415 (2006.01) - 1,2-Diazoles

A61K 31/4406 (2006.01) - only substituted in position 3, e.g. zimeldine

A61K 31/4409 (2006.01) - only substituted in position 4, e.g. isoniazid, iproniazid

C07D 213/56 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 213/57 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 239/26 (2006.01) Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D 261/08 (2006.01) Heterocyclic compounds having nitrogen and oxygen as the only ring hetero atoms

C07D 273/08 (2006.01) Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups

C07D 307/94 (2006.01) Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom

C07D 333/24 (2006.01) Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D 333/38 (2006.01) Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom