Owner Vertex Pharmaceuticals Incorporated

Inventors Silina, Alina; Nakatani, Akiko; GarciaGuzman Blanco, Miguel; Drutu, Ioana; Makings, Lewis R.; Termin, Andreas P.; Bergeron, Daniele M.; Raffai, Gabriel; Hurley, Dennis J.

Agent Spruson & Ferguson

Pub. Number AU-A-2007221220

PCT Pub. Number WO2007/100670

Priority 60/775,501 22.02.06 US; 60/775,524 22.02.06 US

Filing date 22 February 2007

Wipo publication date 7 September 2007

C07D 471/10 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

A61K 31/438 (2006.01) - the ring being spiro-condensed with carbocyclic or heterocyclic ring systems

A61K 31/46 (2006.01) - 8-Azabicyclo [3.2.1] octane

A61K 31/4747 (2006.01) - spiro-condensed

A61P 25/00 (2006.01) Drugs for disorders of the nervous system

C07D 519/00 (2006.01) Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or