Owner Merck & Co., Inc.

Inventors Chang, Linda L; Qi, Hongbo; Guthikonda, Ravindra N; Jewell, James P; Lin, Linus S; Lanza Jr, Thomas J; Armstrong, Helen M; Hagmann, William K; Shah, Shrenik K; Liu, Ping

Agent Spruson & Ferguson

Pub. Number AU-B-2007201276

Parent 2003218068

Filing date 23 March 2007

Wipo publication date 19 April 2007

Acceptance publication date 5 November 2009

C07D 295/14 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

A61K 31/165 (2006.01) - having aromatic rings, e.g. colchicine, atenolol, progabide

A61K 31/27 (2006.01)

A61K 31/40 (2006.01) - having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

A61K 31/4015 (2006.01) - having oxo groups directly attached to the heterocyclic ring, e.g. piracetam, ethosuximide

A61K 31/403 (2006.01) - condensed with carbocyclic rings, e.g. carbazole

A61K 31/405 (2006.01)

A61K 31/415 (2006.01) - 1,2-Diazoles

A61K 31/4192 (2006.01) - 1,2,3-Triazoles

A61K 31/4196 (2006.01) - 1,2,4-Triazoles

A61K 31/42 (2006.01) - Oxazoles

A61K 31/423 (2006.01) - condensed with carbocyclic rings

A61K 31/426 (2006.01) - 1,3-Thiazoles

A61K 31/428 (2006.01) - condensed with carbocyclic rings

A61K 31/437 (2006.01)

A61K 31/44 (2006.01) - Non-condensed pyridines

A61K 31/4402 (2006.01) - only substituted in position 2, e.g. pheniramine, bisacodyl

A61K 31/4409 (2006.01) - only substituted in position 4, e.g. isoniazid, iproniazid

A61K 31/4436 (2006.01)

A61K 31/445 (2006.01) - Non-condensed piperidines, e.g. piperocaine

A61K 31/4453 (2006.01) - only substituted in position 1, e.g. propipocaine, diperodon

A61K 31/4545 (2006.01)

A61K 31/4709 - Non-condensed quinolines containing further heterocyclic rings