Owner Vertex Pharmaceuticals Incorporated

Inventors Kawatkar, Aarti; Arumugam, Vijayalaksmi; Wilson, Dean; Lehsten, Danielle; Neubert, Timothy; Whitney, Tara; Gutierrez, Corey; Fanning, Lev T. D.; Sheth, Urvi; Knoll, Tara; Martinborough, Esther; Zhou, Jinglan; Stamos, Dean; Zimmermann, Nicole; Termin, Andreas

Agent Cullens

Pub. Number AU-B-2006331608

PCT Pub. Number WO2007/075895

Priority 60/799,797 12.05.06 US; 60/839,444 23.08.06 US; 60/752,926 21.12.05 US; 60/791,181 11.04.06 US

Filing date 21 December 2006

Wipo publication date 5 July 2007

Acceptance publication date 5 July 2012

C07D 239/42 Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

A61K 31/506 - not condensed and containing further heterocyclic rings

A61P 25/04 Drugs for disorders of the nervous system

C07D 401/12 Heterocyclic compounds containing two or more hetero rings

C07D 405/12 Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

C07D 417/12 Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 417/14 Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 471/10 Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 491/10 Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or