Owner Vertex Pharmaceuticals Incorporated

Inventors Drutu, Ioana; Hurley, Dennis J.; GarciaGuzman Blanco, Miguel; Makings, Lewis R.; Nakatani, Akiko; Silina, Alina; Raffai, Gabriel; Termin, Andreas P.; Bergeron, Daniele M.

Agent Spruson & Ferguson

Pub. Number AU-A-2006330866

PCT Pub. Number WO2007/076070

Priority 60/753,187 22.12.05 US

Filing date 22 December 2006

Wipo publication date 5 July 2007

A61K 31/435 (2006.01) - having six-membered rings with one nitrogen as the only ring hetero atom

A61K 31/438 (2006.01) - the ring being spiro-condensed with carbocyclic or heterocyclic ring systems

A61K 31/4545 (2006.01)

A61K 31/46 (2006.01) - 8-Azabicyclo [3.2.1] octane

A61K 31/497 (2006.01)

A61K 31/498 (2006.01) - Pyrazines or piperazines ortho- or peri-condensed with carbocyclic ring systems, e.g. quinoxaline, phenazine

A61K 31/501 (2006.01) - not condensed and containing further heterocyclic rings

A61K 31/506 (2006.01) - not condensed and containing further heterocyclic rings

A61P 25/00 (2006.01) Drugs for disorders of the nervous system

A61P 43/00 (2006.01) Drugs for specific purposes, not provided for in groups

C07D 471/00 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 471/10 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups