Owner Alnylam Pharmaceuticals, Inc.

Inventors Roehl, Ingo; Geick, Anke; Tan, Pamela; Sah, Dinah Wen-Yee; Vornlocher, Hans-Peter; Hadwiger, Philipp; FrankKamenetsky, Maria

Agent Griffith Hack

Pub. Number AU-B-2006311725

PCT Pub. Number WO2007/056326

Priority 60/733,816 04.11.05 US; 60/763,202 26.01.06 US; 60/741,586 02.12.05 US; 60/849,364 04.10.06 US; 60/795,443 27.04.06 US

Filing date 3 November 2006

Wipo publication date 18 May 2007

Acceptance publication date 24 November 2011

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

C07F 9/6533 (2006.01) Compounds containing elements of the 5th Group of the Periodic System

C07H 21/02 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07H 21/04 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07J 17/00 (2006.01) Normal steroids containing carbon, hydrogen, halogen, or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta[a]hydrophenanthrene skeleton

C12N 5/10 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

C12N 15/113 (2010.01) Mutation or genetic engineering - Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides