Owner Vertex Pharmaceuticals Incorporated

Inventors Miller, Mark; McCarthy, Jason; Bear, Brian; Zhou, Jinglan; Hamilton, Matthew; Hadida Ruah, Sara; Grootenhuis, Peter D. J.

Agent Cullens

Pub. Number AU-B-2006311650

PCT Pub. Number WO2007/056341

Priority 60/734,506 08.11.05 US; 60/802,458 22.05.06 US; 60/754,086 27.12.05 US

Filing date 8 November 2006

Wipo publication date 18 May 2007

Acceptance publication date 23 February 2012

C07D 405/12 (2006.01) Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

A61K 31/4418 (2006.01) - having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine

A61K 31/5585 (2006.01)

A61P 11/00 (2006.01) Drugs for disorders of the respiratory system

C07D 213/75 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 405/14 (2006.01) Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom