Owner Alnylam Pharmaceuticals, Inc.

Inventors Tan, Pamela; Novobrantseva, Tatiana; Geick, Anke; Meyers, Rachel; De Fougerolles, Antonin

Agent Griffith Hack

Pub. Number AU-A-2006308716

PCT Pub. Number WO2007/053696

Priority 60/748,317 07.12.05 US; 60/732,243 01.11.05 US; 60/799,000 09.05.06 US

Filing date 1 November 2006

Wipo publication date 10 May 2007

C07H 21/02 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

A61K 31/7105 (2006.01) - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links

A61K 31/7115 (2006.01) - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine

A61K 31/712 (2006.01) - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose

A61K 31/7125 (2006.01) - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters

A61K 31/713 (2006.01) - Double-stranded nucleic acids or oligonucleotides

A61P 31/16 (2006.01) Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics