Owner Amgen Inc.

Inventors Xu, Shimin; Sham, Kelvin K.c.; Zhang, Dawei; Pettus, Liping H.; Cao, GuoQiang; Reed, Anthony; Rzasa, Robert M.; Chakrabarti, Partha Pratim; Hungate, Randall W.; Tasker, Andrew; Falsey, James Richard; Thaman, Maya C.; Herberich, Bradley J.

Agent Shelston IP

Pub. Number AU-B-2006218449

PCT Pub. Number WO2006/094187

Priority 11/367,123 02.03.06 US; 60/659,003 03.03.05 US

Filing date 3 March 2006

Wipo publication date 8 September 2006

Acceptance publication date 3 December 2009

C07D 237/32 (2006.01) Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

A61K 31/502 (2006.01) - ortho- or peri-condensed with carbocyclic ring systems, e.g. cinnoline, phthalazine

A61P 29/00 (2006.01) Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

C07D 237/30 (2006.01) Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

C07D 237/34 (2006.01) Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings

C07D 401/04 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 403/04 (2006.01) Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group

C07D 409/04 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

C07D 413/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 417/04 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 417/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 487/04 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups

C07D 491/10 (2006.01) Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or

C07D 498/04 (2006.01) Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms