Owner Kalypsys, Inc.

Inventors Zhao, Cunxiang; Kahraman, Mehmet; Govek, Steven. P.; Malecha, James W.; Noble, Stewart A.; Shiau, Andrew; Bayne, Christopher, D.; Lou, Boliang; Duron, Sergio G.; Lindstrom, Andrew; Sertic, Michael; Oshiro, Guy; Robinson, Carmen K. M.

Agent EF WELLINGTON & CO

Pub. Number AU-B-2005307006

PCT Pub. Number WO2006/055187

Priority 60/623,252 29.10.04 US; 60/679,813 11.05.05 US

Filing date 25 October 2005

Wipo publication date 26 May 2006

Acceptance publication date 3 May 2012

C07D 295/22 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

A61K 31/496 (2006.01) - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene

A61K 31/4965 (2006.01) - Non-condensed pyrazines

A61K 31/4985 (2006.01) - Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

C07D 209/08 (2006.01) Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom

C07D 211/96 (2006.01) Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings

C07D 213/74 (2006.01) Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members

C07D 257/04 (2006.01) Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms

C07D 333/60 (2006.01) Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom

C07D 401/12 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 405/04 (2006.01) Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

C07D 409/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

C07D 471/08 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 487/08 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups