Owner Vertex Pharmaceuticals Incorporated

Inventors Lin, Kai; Lin, Chao

Agent Wrays

Pub. Number AU-B-2004285019

PCT Pub. Number WO2005/042570

Priority 60/514,740 27.10.03 US; 60/561,662 13.04.04 US; 60/525,222 26.11.03 US

Filing date 27 October 2004

Wipo publication date 12 May 2005

Acceptance publication date 22 September 2011

C12N 9/50 (2006.01) Enzymes, e.g. ligases (6.) - Proteinases

A61K 31/4709 (2006.01) - Non-condensed quinolines containing further heterocyclic rings

A61K 38/05 (2006.01) Medicinal preparations containing peptides - Dipeptides

A61K 38/16 (2006.01) Medicinal preparations containing peptides - Peptides having more than 20 amino acids

C07H 21/04 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07K 14/18 (2006.01) Peptides having more than 20 amino acids

C12N 9/48 (2006.01) Enzymes, e.g. ligases (6.) - acting on peptide bonds, e.g. thromboplastin, leucine aminopeptidase (3.4)

C12N 15/51 (2006.01) Mutation or genetic engineering - Hepatitis viruses

C12N 15/86 (2006.01) Mutation or genetic engineering - Viral vectors

C12Q 1/37 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving peptidase or proteinase

C12Q 1/70 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving virus or bacteriophage

G01N 33/50 (2006.01) Investigating or analysing materials by specific methods not covered by groups - Chemical analysis of biological material, e.g. blood, urine

G01N 33/68 (2006.01) Investigating or analysing materials by specific methods not covered by groups - involving proteins, peptides or amino acids

G06F 17/50 (2006.01) Digital computing or data processing equipment or methods, specially adapted for specific functions - Computer-aided design

C12Q 1/68 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving nucleic acids