1,4-disubstituted isoquinilone derivatives as RAF-kinase inhibitors useful for the treatment of proliferative diseases

Details for Australian Patent Application No. 2004274173 (hide)

Owner Novartis AG

Inventors Sabio, Michael Lloyd; Ramsey, Timothy Michael; Perez, Lawrence Blas; Yusuff, Naeem; Batt, David Bryant; Fink, Cynthia Anne; Versace, Richard William; Kim, Sunkyu

Agent Davies Collison Cave

Pub. Number AU-A-2004274173

PCT Pub. Number WO2005/028444

Priority 60/505,457 24.09.03 US

Filing date 23 September 2004

Wipo publication date 31 March 2005

International Classifications

C07D 217/22 (2006.01) Heterocyclic compounds containing isoquinoline or hydrogenated isoquinoline ring systems

A61K 31/4725 (2006.01)

A61P 35/00 (2006.01) Antineoplastic agents

C07D 401/04 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 401/14 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 405/04 (2006.01) Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

C07D 405/14 (2006.01) Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

C07D 409/14 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms

C07D 413/04 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 413/10 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 413/14 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 417/14 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

Event Publications

6 April 2006 PCT application entered the National Phase

  PCT publication WO2005/028444 Priority application(s): WO2005/028444

21 May 2009 Application Lapsed, Refused Or Withdrawn, Patent Ceased or Expired

  This application lapsed under section 142(2)(e). Examination has been requested or an examination report has issued for this application. Note that applications or patents shown as lapsed or ceased may be restored at a later date.

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