Owner Pharma Mar, S.A.

Inventors Velasco Iglesias, Ana; Acebo Pais, Paloma; Henriquez Palaez, Ruben; Schleissner Sanchez, Carmen; Rodriguez Ramoz, Pilar; Reyes Benitez, Fernando; De La Calle, Fernando; Aparicio Perez, Tomas

Agent Griffith Hack

Pub. Number AU-B-2003290288

PCT Number PCT/GB2003/0055

PCT Pub. Number WO2004/056998

Priority 0229793.5 20.12.02 GB

Filing date 19 December 2003

Wipo publication date 14 July 2004

Acceptance publication date 2 July 2009

C12N 15/52 (2006.01) Mutation or genetic engineering - Genes encoding for enzymes or proenzymes

A61K 31/4995 (2006.01) - Pyrazines or piperazines forming part of bridged ring systems

A61P 31/04 (2006.01) Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

A61P 35/00 (2006.01) Antineoplastic agents

C07D 401/12 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 403/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group

C07D 413/14 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 471/04 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 471/14 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 471/18 (2006.01) Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07K 14/21 (2006.01) Peptides having more than 20 amino acids

C12N 9/00 (2006.01) Enzymes, e.g. ligases (6.)

C12N 9/02 (2006.01) Enzymes, e.g. ligases (6.) - Oxidoreductases (1.), e.g. luciferase

C12N 9/10 (2006.01) Enzymes, e.g. ligases (6.) - Transferases (2.)

C12N 15/53 (2006.01) Mutation or genetic engineering - Oxidoreductases (1)

C12N 15/54 (2006.01) Mutation or genetic engineering - Transferases (2)

C12P 17/12 (2006.01) Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms

C12P 17/18 (2006.01) Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms - containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin