Methods for the preparation, isolation and purification of epothilone B, and XRay crystal structures of epothilone B

Details for Australian Patent Application No. 2003275068 (hide)

Owner Bristol-Myers Squibb Company

Inventors Mascari, Mark; Hou, David; Benigni, Daniel; Comezoglu, Fahri T.; Davis, Brian L.; Chiang, Shu-Jen; Galvin, Gabriel; Gu, Dennis; Tully, Thomas P.; Stein, Gregory; Eagan, Bruce; Mintzmyer, Les; Hou, Hsing; McConlogue, Cary W.; Stankavage, Robert; Hargro, Ivan

Agent Phillips Ormonde Fitzpatrick

Pub. Number AU-B-2003275068

PCT Number PCT/US03/29628

PCT Pub. Number WO2004/026254

Priority 60/412,994 23.09.02 US

Filing date 22 September 2003

Wipo publication date 8 April 2004

Acceptance publication date 17 September 2009

International Classifications

C12P 17/02 (2006.01) Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms - Oxygen as only ring hetero atoms

C07D 417/02 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 417/06 (2006.01) Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 493/00 (2006.01) Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system

C07D 493/04 (2006.01) Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system

C12N 1/20 (2006.01) Micro-organisms, e.g. protozoa - Bacteria

C12N 5/06 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines -

C12N 9/52 (2006.01) Enzymes, e.g. ligases (6.) - derived from bacteria

C12P 17/14 (2006.01) Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms - Nitrogen or oxygen as hetero atom and at least one other diverse hetero ring atom in the same ring

C12P 17/16 (2006.01) Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms - containing two or more hetero rings

C12P 17/18 (2006.01) Preparation of heterocyclic carbon compounds with only O, N, S, Se, or Te as ring hetero atoms - containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin

Event Publications

12 February 2004 Complete Application Filed

  Priority application(s): 60/412,994 23.09.02 US

20 May 2004 Application Open to Public Inspection

  Published as AU-B-2003275068

17 September 2009 Application Accepted

  Published as AU-B-2003275068

21 January 2010 Standard Patent Sealed

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