Owner Proteotech, Inc.

Inventors Snow, Alan D.; Larsen, Lesley; Lorimer, Stephen D.; Sanders, Virginia J.; Nguyen, Beth P.; Weavers, Rex T.; Coffen, David L.; Larsen, David S.; Castillo, Gerardo M.; Lake, Thomas P.

Agent Spruson & Ferguson

Pub. Number AU-B-2003249678

PCT Number PCT/US03/17288

PCT Pub. Number WO2003/101927

Priority 60/409,100 09.09.02 US; 60/435,880 20.12.02 US; 60/463,104 14.04.03 US; 60/385,144 31.05.02 US; 60/412,272 20.09.02 US

Filing date 30 May 2003

Wipo publication date 19 December 2003

Acceptance publication date 19 March 2009

C07D 295/08 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

A61K 31/05 (2006.01)

A61K 31/121 (2006.01) - acyclic

A61K 31/137 (2006.01) - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine

A61K 31/165 (2006.01) - having aromatic rings, e.g. colchicine, atenolol, progabide

A61K 31/166 (2006.01) - having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol

A61K 31/167 (2006.01) - having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

A61K 31/17 (2006.01) - having the group NC(O)N or NC(S)N, e.g. urea, thiourea, carmustine

A61K 31/4375 (2006.01)

A61K 31/439 (2006.01) - the ring forming part of a bridged ring system, e.g. quinuclidine

A61K 31/4418 (2006.01) - having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine

A61K 31/495 (2006.01) - having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

A61P 5/00 (2006.01) Drugs for disorders of the endocrine system

A61P 25/00 (2006.01) Drugs for disorders of the nervous system

A61P 25/28 (2006.01) Drugs for disorders of the nervous system

A61P 35/00 (2006.01) Antineoplastic agents

A61P 43/00 (2006.01) Drugs for specific purposes, not provided for in groups

C07C 37/055 (2006.01) Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom of a six-membered aromatic ring

C07C 39/15 (2006.01) Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring

C07C 39/16 (2006.01) Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring

C07C 39/17 (2006.01) Compounds having at least one hydroxy or O-metal group bound to a carbon atom of a six-membered aromatic ring

C07C 45/62 (2006.01) Preparation of compounds having CO groups bound only to carbon or hydrogen atoms