Processes for preparing substituted pyrimidines and pyrimidine derivatives as inhibitors of protein kinase

Details for Australian Patent Application No. 2003245568 (hide)

Owner Vertex Pharmaceuticals Incorporated

Inventors Mazzei, Francesca; Miller, Andrew; Kay, David; Charrier, Jean-Damien

Agent Cullens

Pub. Number AU-B-2003245568

PCT Number PCT/US03/19266

PCT Pub. Number WO2004/000833

Priority 60/390,658 20.06.02 US; 60/411,609 18.09.02 US

Filing date 19 June 2003

Wipo publication date 6 January 2004

Acceptance publication date 17 December 2009

International Classifications

C07D 403/12 (2006.01) Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group

A61K 31/439 (2006.01) - the ring forming part of a bridged ring system, e.g. quinuclidine

A61K 31/506 (2006.01) - not condensed and containing further heterocyclic rings

A61K 31/5377 (2006.01)

A61K 31/541 (2006.01) - Non-condensed thiazines containing further heterocyclic rings

A61K 31/551 (2006.01) - having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep

A61P 3/00 (2006.01) Drugs for disorders of the metabolism

A61P 5/00 (2006.01) Drugs for disorders of the endocrine system

A61P 9/00 (2006.01) Drugs for disorders of the cardiovascular system

A61P 11/06 (2006.01) Drugs for disorders of the respiratory system

A61P 13/08 (2006.01) Drugs for disorders of the urinary system

A61P 19/00 (2006.01) Drugs for skeletal disorders

A61P 25/00 (2006.01) Drugs for disorders of the nervous system

A61P 25/28 (2006.01) Drugs for disorders of the nervous system

A61P 29/00 (2006.01) Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

A61P 35/00 (2006.01) Antineoplastic agents

A61P 35/02 (2006.01) Antineoplastic agents

A61P 37/06 (2006.01) Drugs for immunological or allergic disorders

A61P 37/08 (2006.01) Drugs for immunological or allergic disorders

A61P 43/00 (2006.01) Drugs for specific purposes, not provided for in groups

C07D 239/34 (2006.01) Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07D 401/14 (2006.01) Heterocyclic compounds containing two or more hetero rings

C07D 403/14 (2006.01) Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group

C07D 453/02 Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids

Event Publications

25 September 2003 Complete Application Filed

  Priority application(s): 60/390,658 20.06.02 US; 60/411,609 18.09.02 US

4 March 2004 Application Open to Public Inspection

  Published as AU-B-2003245568

6 November 2008 Alteration of Name

  The name of the applicant has been altered to Vertex Pharmaceuticals Incorporated

17 December 2009 Application Accepted

  Published as AU-B-2003245568

15 April 2010 Standard Patent Sealed

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