Owner California Pacific Medical Center

Inventors Zheng, Wei-Wen; Kirpotin, Dmitri B.; Hayes, Mark Eamon; Drummond, Daryl C.; Hong, Keelung

Agent Phillips Ormonde Fitzpatrick

Pub. Number AU-B-2003237864

PCT Number PCT/US03/15378

PCT Pub. Number WO2003/097805

Priority 60/381,417 15.05.02 US

Filing date 15 May 2003

Wipo publication date 2 December 2003

Acceptance publication date 18 December 2008

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 9/127 (2006.01) Medicinal preparations characterised by special physical form - Liposomes

A61K 9/22 (2006.01) Medicinal preparations characterised by special physical form - Sustained or differential release type

A61K 9/32 (2006.01) Medicinal preparations characterised by special physical form

A61K 9/51 (2006.01) Medicinal preparations characterised by special physical form - Nanocapsules

A61K 31/7088 (2006.01) - Compounds having three or more nucleosides or nucleotides

A61K 47/14 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Esters of carboxylic acids

A61K 47/24 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur

A61K 47/28 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Steroids

A61K 47/34 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

C12N 5/10 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells