Owner Amgen Inc.

Inventors Kelly, Michael G.; Coulter, Thomas; Kincaid, John F.; XiI, Ning; Miller, Philip; Ghiron, Chiara; Xu, Shimin

Agent Shelston IP

Pub. Number AU-B-2003233671

PCT Number PCT/US03/16401

PCT Pub. Number WO2003/099776

Priority 60/441,065 17.01.03 US; 10/444,946 22.05.03 US; 60/383,050 23.05.02 US

Filing date 23 May 2003

Wipo publication date 12 December 2003

Acceptance publication date 16 August 2007

C07C 317/32 (2006.01) Sulfones

A61K 31/137 (2006.01) - Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine

A61K 31/145 (2006.01) - having sulfur atoms, e.g. thiurams (NC(S)SC(S)N or NC(S)SSC(S)N)

A61K 31/167 (2006.01) - having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

A61K 31/275 (2006.01) - Nitriles

A61K 31/341 (2006.01) - not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine

A61K 31/357 (2006.01) - having two or more oxygen atoms in the same ring, e.g. crown ethers, guanadrel

A61K 31/36 (2006.01)

A61K 31/381 (2006.01) - having five-membered rings

A61K 31/4045 (2006.01)

A61K 31/417 (2006.01)

A61K 31/4184 (2006.01)

A61K 31/42 (2006.01) - Oxazoles

A61K 31/423 (2006.01) - condensed with carbocyclic rings

A61K 31/426 (2006.01) - 1,3-Thiazoles

A61K 31/4418 (2006.01) - having a carbocyclic ring directly attached to the heterocyclic ring, e.g. cyproheptadine

A61K 31/443 (2006.01)

A61K 31/4439 (2006.01)

A61K 31/4465 (2006.01) - only substituted in position 4

A61K 31/47 (2006.01) - Quinolines

A61K 31/4965 (2006.01) - Non-condensed pyrazines

A61K 31/50 (2006.01) - Pyridazines

A61K 31/505 - Pyrimidines