Owner The Trustees of Columbia University in the City of New York

Inventors Itescu, Silviu

Agent FB Rice

Pub. Number AU-B-2003231090

PCT Number PCT/US03/12768

PCT Pub. Number WO2003/090512

Priority 10/128,738 23.04.02 US

Filing date 23 April 2003

Wipo publication date 10 November 2003

Acceptance publication date 1 October 2009

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 31/045 (2006.01) - Hydroxy compounds, e.g. alcohols

A61K 31/7088 (2006.01) - Compounds having three or more nucleosides or nucleotides

A61K 31/711 (2006.01) - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

A61K 35/32 (2006.01) Medicinal preparations containing material or reaction products thereof with undetermined constitution - Bones

A61K 35/36 (2006.01) Medicinal preparations containing material or reaction products thereof with undetermined constitution - Skin

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 38/18 (2006.01) Medicinal preparations containing peptides - Growth factors

A61K 38/19 (2006.01) Medicinal preparations containing peptides - Cytokines

A61K 38/22 (2006.01) Medicinal preparations containing peptides - Hormones

A61K 39/395 (2006.01) Medicinal preparations containing antigens or antibodies - Antibodies

A61K 45/00 (2006.01) Medicinal preparations containing active ingredients not provided for in groups

A61P 7/02 (2006.01) Drugs for disorders of the blood or the extracellular fluid

A61P 9/00 (2006.01) Drugs for disorders of the cardiovascular system

A61P 9/04 (2006.01) Drugs for disorders of the cardiovascular system

A61P 9/10 (2006.01) Drugs for disorders of the cardiovascular system

A61P 43/00 (2006.01) Drugs for specific purposes, not provided for in groups

C07K 16/28 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C12N 5/06 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines -

C12N 5/08 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines -

C12N 15/11 (2006.01) Mutation or genetic engineering - DNA or RNA fragments

C12Q 1/02 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving viable micro-organisms

C12Q 1/68 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving nucleic acids

A61K 35/12 (2006.01) Medicinal preparations containing material or reaction products thereof with undetermined constitution - Materials from mammals or birds