Owner GTC BIOTHERAPEUTICS, INC.

Inventors Melican, David; Gavin, William G; Butler, Robin E

Agent Davies Collison Cave

Pub. Number AU-A-2003230725

PCT Number PCT/US03/09054

PCT Pub. Number WO2003/085105

Priority 60/369,009 01.04.02 US

Filing date 25 March 2003

Wipo publication date 20 October 2003

C12N 015/00 Mutation or genetic engineering

C12N 015/85 Mutation or genetic engineering - for animal cells

C12N 015/87 Mutation or genetic engineering - Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation

C12N 015/09 Mutation or genetic engineering - Recombinant DNA-technology

C12N 015/70 Mutation or genetic engineering - Vectors or expression systems specially adapted for E. coli

C12N 015/74 Mutation or genetic engineering - Vectors or expression systems specially adapted for prokaryotic hosts other than E. coli, e.g. Lactobacillus, Micromonospora

C12N 005/00 Undifferentiated human, animal or plant cells, e.g. cell lines

C12N 005/02 Undifferentiated human, animal or plant cells, e.g. cell lines - Propagation of single cells or cells in suspension

C12N 015/63 Mutation or genetic engineering - Introduction of foreign genetic material using vectors