Owner Amgen Inc.

Inventors Xiong, Fei; Walker, Kenneth

Agent Shelston IP

Pub. Number AU-B-2003224844

PCT Number PCT/US03/10443

PCT Pub. Number WO2003/086444

Priority 10/117,109 04.04.02 US

Filing date 3 April 2003

Wipo publication date 27 October 2003

Acceptance publication date 21 May 2009

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 38/17 (2006.01) Medicinal preparations containing peptides - from animals

A61K 38/44 (2006.01) Medicinal preparations containing peptides

A61K 47/32 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

A61K 47/34 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

A61K 47/36 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Polysaccharides

A61K 47/42 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Proteins

A61K 47/48 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

A61P 7/04 (2006.01) Drugs for disorders of the blood or the extracellular fluid

C07K 14/435 (2006.01) Peptides having more than 20 amino acids - from animals

C07K 14/475 (2006.01) Peptides having more than 20 amino acids

C07K 14/605 (2006.01) Peptides having more than 20 amino acids

C07K 17/08 (2006.01) Carrier-bound or immobilised peptides

C07K 19/00 (2006.01) Hybrid peptides