Owner Schering Corporation

Inventors Bober, Loretta A; Taveras, Arthur G; Lundell, Daniel; Fine, Jay S; Biju, Purakkattle; Chao, Jianhua; Kreutner, William; Billah, Motasim; Jakway, James; Yu, Younong

Agent Griffith Hack

Pub. Number AU-B-2003220384

PCT Number PCT/US03/08287

PCT Pub. Number WO2003/080053

Priority 60/365,314 18.03.02 US

Filing date 17 March 2003

Wipo publication date 8 October 2003

Acceptance publication date 10 May 2007

C07D 295/18 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

A61K 31/166 (2006.01) - having the carbon atom of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol

A61K 31/167 (2006.01) - having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

A61K 31/277 (2006.01)

A61K 31/341 (2006.01) - not condensed with another ring, e.g. ranitidine, furosemide, bufetolol, muscarine

A61K 31/351 (2006.01) - not condensed with another ring

A61K 31/36 (2006.01)

A61K 31/381 (2006.01) - having five-membered rings

A61K 31/397 (2006.01) - having four-membered rings, e.g. azetidine

A61K 31/40 (2006.01) - having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

A61K 31/401 (2006.01) - Proline

A61K 31/415 (2006.01) - 1,2-Diazoles

A61K 31/422 (2006.01) - not condensed and containing further heterocyclic rings

A61K 31/427 (2006.01) - not condensed and containing further heterocyclic rings

A61K 31/4412 (2006.01) - having oxo groups directly attached to the heterocyclic ring

A61K 31/4422 (2006.01) - 1,4-Dihydropyridines, e.g. nifedipine, nicardipine

A61K 31/443 (2006.01)

A61K 31/455 (2006.01) - Nicotinic acid, i.e. niacin

A61K 31/495 (2006.01) - having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

A61K 31/496 (2006.01) - Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene

A61K 31/505 (2006.01) - Pyrimidines

A61K 31/506 (2006.01) - not condensed and containing further heterocyclic rings

A61K 31/53 - having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine