Owner VERTEX PHARMACEUTICALS, INC.

Inventors KNEGTEL, Ronald; MILLER, Andrew; PIERARD, Francoise; BEBBINGTON, David; BINCH, Hayley; CHARRIER, Jean-Damien; EVERITT, Simon; GOLEC, Julian, M., C.; KAY, David

Pub. Number AU-A-2003218215

PCT Number PCT/US03/08125

PCT Pub. Number WO2003/078427

Priority 60/364,864 15.03.02 US

Filing date 14 March 2003

Wipo publication date 29 September 2003

C07D 417/12 Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

C07D 471/04 Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups

C07D 487/04 Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups

C07D 413/12 Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 413/14 Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms

C07D 417/14 Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group

A61K 031/505 - Pyrimidines

A61P 037/00 Drugs for immunological or allergic disorders

A61P 031/12 Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

A61P 035/00 Antineoplastic agents

A61P 009/00 Drugs for disorders of the cardiovascular system

A61P 007/00 Drugs for disorders of the blood or the extracellular fluid

A61P 019/00 Drugs for skeletal disorders

A61P 003/00 Drugs for disorders of the metabolism

C07D 411/12 Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen and sulfur atoms as the only ring hetero atoms