Owner Sirna Therapeutics, Inc.

Inventors Fosnaugh, Kathy; McSwiggen, James; Jamison, Sharon; Thompson, James; Chowrira, Bharat; Pavco, Pamela; Beigelman, Leonid; Usman, Nassim

Agent Spruson & Ferguson

Pub. Number AU-B-2003216324

PCT Number PCT/US03/05028

PCT Pub. Number WO2003/074654

Priority 60/440,129 15.01.03 US; 60/408,378 05.09.02 US; 60/386,782 06.06.02 US; 60/406,784 29.08.02 US; 60/409,293 09.09.02 US; 60/358,580 20.02.02 US; 60/363,124 11.03.02 US

Filing date 20 February 2003

Wipo publication date 16 September 2003

Acceptance publication date 26 February 2009

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 31/7088 (2006.01) - Compounds having three or more nucleosides or nucleotides

A61K 31/7105 (2006.01) - Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links

A61K 31/711 (2006.01) - Natural deoxyribonucleic acids, i.e. containing only 2'-deoxyriboses attached to adenine, guanine, cytosine or thymine and having 3'-5' phosphodiester links

A61K 31/7115 (2006.01) - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine

A61K 31/712 (2006.01) - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose

A61K 31/7125 (2006.01) - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters

A61K 31/713 (2006.01) - Double-stranded nucleic acids or oligonucleotides

A61K 47/48 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 1/00 (2006.01) Drugs for disorders of the alimentary tract or the digestive system

A61P 1/04 (2006.01) Drugs for disorders of the alimentary tract or the digestive system

A61P 1/16 (2006.01) Drugs for disorders of the alimentary tract or the digestive system

A61P 3/00 (2006.01) Drugs for disorders of the metabolism

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

A61P 11/06 (2006.01) Drugs for disorders of the respiratory system

A61P 13/08 (2006.01) Drugs for disorders of the urinary system

A61P 13/10 (2006.01) Drugs for disorders of the urinary system

A61P 13/12 (2006.01) Drugs for disorders of the urinary system

A61P 17/00 (2006.01) Drugs for dermatological disorders

A61P 17/02 (2006.01) Drugs for dermatological disorders

A61P 19/00 (2006.01) Drugs for skeletal disorders

A61P 19/02 (2006.01) Drugs for skeletal disorders

A61P 21/00 Drugs for disorders of the muscular or neuromuscular system