Owner Genentech, Inc.

Inventors Zhang, Zemin; Wood, William I; Seshagiri, Somasekar; Stinson, Jeremy; Grimaldi, Christopher J

Agent Griffith Hack

Pub. Number AU-B-2003213166

PCT Number PCT/US03/05169

PCT Pub. Number WO2003/076569

Priority 60/361,995 05.03.02 US

Filing date 18 February 2003

Wipo publication date 22 September 2003

Acceptance publication date 3 July 2008

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 39/395 (2006.01) Medicinal preparations containing antigens or antibodies - Antibodies

A61K 45/00 (2006.01) Medicinal preparations containing active ingredients not provided for in groups

A61P 21/00 (2006.01) Drugs for disorders of the muscular or neuromuscular system

A61P 25/00 (2006.01) Drugs for disorders of the nervous system

A61P 25/16 (2006.01) Drugs for disorders of the nervous system

A61P 25/28 (2006.01) Drugs for disorders of the nervous system

A61P 43/00 (2006.01) Drugs for specific purposes, not provided for in groups

C07K 14/705 (2006.01) Peptides having more than 20 amino acids

C07K 14/71 (2006.01) Peptides having more than 20 amino acids

C07K 16/28 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C07K 19/00 (2006.01) Hybrid peptides

C12N 1/15 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 1/19 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 1/21 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 5/10 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

C12P 21/02 (2006.01) Preparation of peptides or proteins - having a known sequence of two or more amino acids, e.g. glutathione

C12P 21/08 (2006.01) Preparation of peptides or proteins - Monoclonal antibodies