Owner Merck & Co., Inc.

Inventors Fraley, Mark E; Hartman, George D

Agent Spruson & Ferguson

Pub. Number AU-B-2002364128

PCT Number PCT/US02/38487

PCT Pub. Number WO2003/050122

Priority 60/338,380 06.12.01 US

Filing date 2 December 2002

Wipo publication date 23 June 2003

Acceptance publication date 6 March 2008

C07D 491/048 (2006.01) Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or

A61K 31/138 (2006.01) - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine

A61K 31/4465 (2006.01) - only substituted in position 4

A61K 31/4535 (2006.01)

A61K 31/519 (2006.01) - ortho- or peri-condensed with heterocyclic rings

A61K 31/5377 (2006.01)

A61K 31/541 (2006.01) - Non-condensed thiazines containing further heterocyclic rings

A61K 31/551 (2006.01) - having two nitrogens as ring hetero atoms, e.g. clozapine, dilazep

A61K 31/5517 (2006.01)

A61K 39/395 (2006.01) Medicinal preparations containing antigens or antibodies - Antibodies

A61K 45/00 (2006.01) Medicinal preparations containing active ingredients not provided for in groups

A61P 35/00 (2006.01) Antineoplastic agents

C07D 491/04 (2006.01) Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups , , or

C07D 519/00 (2006.01) Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups or