Owner Merck & Co., Inc. Istituto di Ricerche di Biologia Molecolare P. Angeletti S.p.A

Inventors Lahm, Armin; Colloca, Stefano; Shiver, John W; Emini, Emilio A; Kaslow, David C; Bett, Andrew J; Cortese, Riccardo; Luzzago, Alessandra; Nicosia, Alfredo

Agent Spruson & Ferguson

Pub. Number AU-B-2002337840

PCT Number PCT/US02/32512

PCT Pub. Number WO2003/031588

Priority 60/363,774 13.03.02 US; 60/328,655 11.10.01 US

Filing date 10 October 2002

Wipo publication date 22 April 2003

Acceptance publication date 9 August 2007

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 35/76 (2006.01) Medicinal preparations containing material or reaction products thereof with undetermined constitution

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 39/00 (2006.01) Medicinal preparations containing antigens or antibodies

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 31/14 (2006.01) Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics

C07K 14/18 (2006.01) Peptides having more than 20 amino acids

C12N 1/15 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 1/19 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 1/21 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 5/10 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

C12N 15/40 (2006.01) Mutation or genetic engineering - Proteins from RNA viruses, e.g. flaviviruses

C12N 15/51 (2006.01) Mutation or genetic engineering - Hepatitis viruses

C12N 15/861 (2006.01) Mutation or genetic engineering - Adenoviral vectors