Owner Isis Pharmaceuticals, Inc.

Inventors Tillman, Lloyd G.; Geary, Richard S.; Weinbach, Susan P.; Hardee, Gregory E.

Agent FB Rice

Pub. Number AU-B-2002332647

PCT Number PCT/US02/26924

PCT Pub. Number WO2003/017940

Priority 09/944,493 22.08.01 US

Filing date 22 August 2002

Wipo publication date 10 March 2003

Acceptance publication date 15 May 2008

A61K 47/12 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Carboxylic acids

A61K 9/20 (2006.01) Medicinal preparations characterised by special physical form - Pills, lozenges or tablets

A61K 9/22 (2006.01) Medicinal preparations characterised by special physical form - Sustained or differential release type

A61K 9/24 (2006.01) Medicinal preparations characterised by special physical form - Layered or laminated unitary dosage forms

A61K 9/26 (2006.01) Medicinal preparations characterised by special physical form - Discrete particles in supporting matrix

A61K 9/28 (2006.01) Medicinal preparations characterised by special physical form - Dragees

A61K 9/42 (2006.01) Medicinal preparations characterised by special physical form

A61K 9/48 (2006.01) Medicinal preparations characterised by special physical form - Preparations in capsules, e.g. of gelatin, of chocolate

A61K 9/52 (2006.01) Medicinal preparations characterised by special physical form - Sustained or differential release type

A61K 9/54 (2006.01) Medicinal preparations characterised by special physical form

A61K 9/66 (2006.01) Medicinal preparations characterised by special physical form

A61K 31/7088 (2006.01) - Compounds having three or more nucleosides or nucleotides

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 39/00 (2006.01) Medicinal preparations containing antigens or antibodies

A61K 39/395 (2006.01) Medicinal preparations containing antigens or antibodies - Antibodies

A61K 47/04 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives

A61K 47/08 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - containing oxygen

A61K 47/14 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Esters of carboxylic acids

A61K 47/16 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - containing nitrogen

A61K 47/18 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives

A61K 47/22 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Heterocyclic compounds

A61K 47/26 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Carbohydrates

A61K 47/28 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Steroids

A61K 47/32 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds