Owner The General Hospital Corporation

Inventors Nolan, Anna, Louise; Habener, Joel, F.; Leech, Colin, A.; Abraham, Elizabeth, J.; Lechner, Andreas; Zulewski, Henryk; Thomas, Melissa, K.; Vallejo, Mario

Agent Wrays

Pub. Number AU-B-2002331910

PCT Number PCT/US02/30700

PCT Pub. Number WO2003/026584

Priority 10/136,891 02.05.02 US; 10/120,687 11.04.02 US; 09/963,875 26.09.01 US

Filing date 26 September 2002

Wipo publication date 7 April 2003

Acceptance publication date 11 October 2007

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A01K 67/027 (2006.01) Rearing or breeding animals, not otherwise provided for - New breeds of vertebrates

A61K 31/436 (2006.01)

A61K 31/7088 (2006.01) - Compounds having three or more nucleosides or nucleotides

A61K 35/39 (2006.01) Medicinal preparations containing material or reaction products thereof with undetermined constitution

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 38/22 (2006.01) Medicinal preparations containing peptides - Hormones

A61K 45/00 (2006.01) Medicinal preparations containing active ingredients not provided for in groups

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

C12N 5/02 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Propagation of single cells or cells in suspension

C12N 5/06 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines -

C12N 5/08 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines -

C12Q 1/00 (2006.01) Measuring or testing processes involving enzymes or micro-organisms

G01N 33/53 (2006.01) Investigating or analysing materials by specific methods not covered by groups - Immunoassay

A61K 35/12 (2006.01) Medicinal preparations containing material or reaction products thereof with undetermined constitution - Materials from mammals or birds