Owner Isis Pharmaceuticals, Inc.

Inventors Graham, Mark J.; Crooke, Rosanne M.

Agent Wrays

Pub. Number AU-B-2002326481

PCT Number PCT/US02/24247

PCT Pub. Number WO2003/011887

Priority 09/920,033 01.08.01 US; 10/147,196 15.05.02 US; 10/135,985 30.04.02 US

Filing date 30 July 2002

Wipo publication date 17 February 2003

Acceptance publication date 13 November 2008

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 31/7088 (2006.01) - Compounds having three or more nucleosides or nucleotides

A61K 31/7115 (2006.01) - Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine

A61K 31/712 (2006.01) - Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose

A61K 31/7125 (2006.01) - Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 3/04 (2006.01) Drugs for disorders of the metabolism

A61P 3/06 (2006.01) Drugs for disorders of the metabolism

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

A61P 9/10 (2006.01) Drugs for disorders of the cardiovascular system

C07H 21/04 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C12N 15/11 (2006.01) Mutation or genetic engineering - DNA or RNA fragments

A61K 38/00 (2006.01) Medicinal preparations containing peptides