Owner The Trustees of the University of Pennsylvania

Inventors Diamond, Scott L.; Gruneich, Jeffrey

Agent Pizzeys

Pub. Number AU-B-2002324723

PCT Number PCT/US02/26152

PCT Pub. Number WO2003/015757

Priority 60/312,729 16.08.01 US; 60/358,138 20.02.02 US

Filing date 15 August 2002

Wipo publication date 3 March 2003

Acceptance publication date 25 October 2007

A61K 47/48 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

A61K 9/22 (2006.01) Medicinal preparations characterised by special physical form - Sustained or differential release type

A61K 31/366 (2006.01) - having six-membered rings, e.g. delta-lactones

A61K 31/4439 (2006.01)

A61K 31/56 (2006.01) - Compounds containing cyclopenta[a]hydrophenanthrene ring systems

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 38/22 (2006.01) Medicinal preparations containing peptides - Hormones

A61K 47/20 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - containing sulfur

A61K 47/24 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur

A61K 47/28 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Steroids

A61K 47/34 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

A61K 47/42 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Proteins

A61K 47/46 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Ingredients of undetermined constitution or reaction products thereof

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61P 1/04 (2006.01) Drugs for disorders of the alimentary tract or the digestive system

A61P 1/14 (2006.01) Drugs for disorders of the alimentary tract or the digestive system

A61P 3/04 (2006.01) Drugs for disorders of the metabolism

A61P 3/06 (2006.01) Drugs for disorders of the metabolism

A61P 3/10 (2006.01) Drugs for disorders of the metabolism

A61P 7/04 (2006.01) Drugs for disorders of the blood or the extracellular fluid

A61P 7/06 (2006.01) Drugs for disorders of the blood or the extracellular fluid

A61P 9/00 (2006.01) Drugs for disorders of the cardiovascular system

A61P 9/10 (2006.01) Drugs for disorders of the cardiovascular system

A61P 9/12 (2006.01) Drugs for disorders of the cardiovascular system