Owner The Scripps Research Institute Board of Trustees of the Leland Stanford, Jr., University

Inventors Hood, John; Bednarski, Mark; Cheresh, David A.

Agent Griffith Hack

Pub. Number AU-B-2002314855

PCT Number PCT/US02/17157

PCT Pub. Number WO2002/097116

Priority 60/294,309 30.05.01 US; 60/345,891 29.10.01 US

Filing date 30 May 2002

Wipo publication date 9 December 2002

Acceptance publication date 9 August 2007

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

A61K 9/127 (2006.01) Medicinal preparations characterised by special physical form - Liposomes

A61K 31/353 (2006.01)

A61K 31/538 (2006.01)

A61K 31/7088 (2006.01) - Compounds having three or more nucleosides or nucleotides

A61K 38/00 (2006.01) Medicinal preparations containing peptides

A61K 47/18 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives

A61K 47/24 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - containing atoms other than carbon, hydrogen, halogen, oxygen, nitrogen or sulfur

A61K 47/28 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Steroids

A61K 47/32 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

A61K 47/34 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

A61K 47/48 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates

A61K 48/00 (2006.01) Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases

A61K 51/12 (2006.01) Preparations containing radioactive substances for use in therapy or testing - characterised by a special physical form, e.g. emulsion, microcapsules, liposomes

A61P 9/00 (2006.01) Drugs for disorders of the cardiovascular system

A61P 27/00 (2006.01) Drugs for disorders of the senses

A61P 35/00 (2006.01) Antineoplastic agents

C07D 239/14 (2006.01) Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings

C07H 21/00 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids