Owner Biogen Idec MA Inc.

Inventors Karpusas, Michael; Garber, Ellen A.; Saldanha, Jose W.; Lyne, Paul D.

Agent Cullen & Co

Pub. Number AU-B-2002258778

PCT Pub. Number WO2002/083854

Priority 60/303,689 06.07.01 US; 60/283,794 13.04.01 US

Filing date 12 April 2002

Wipo publication date 28 October 2002

Acceptance publication date 17 January 2008

G01N 33/50 (2006.01) Investigating or analysing materials by specific methods not covered by groups - Chemical analysis of biological material, e.g. blood, urine

A61K 39/395 (2006.01) Medicinal preparations containing antigens or antibodies - Antibodies

A61K 49/16 (2006.01) Preparations for testing

A61P 29/00 (2006.01) Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

A61P 37/00 (2006.01) Drugs for immunological or allergic disorders

C07H 21/04 (2006.01) Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids

C07K 16/18 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies - against material from animals or humans

C07K 16/24 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C07K 16/28 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C07K 16/46 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies - Hybrid immunoglobulins

C12N 1/00 (2006.01) Micro-organisms, e.g. protozoa

C12N 5/10 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

C12N 5/12 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Fused cells, e.g. hybridomas

C12N 5/20 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - one of the fusion partners being a B lymphocyte

C12N 5/22 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Human cells

C12N 9/00 (2006.01) Enzymes, e.g. ligases (6.)

C12N 15/07 (2006.01) Mutation or genetic engineering - Human cells

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

C12N 15/11 (2006.01) Mutation or genetic engineering - DNA or RNA fragments

C12N 15/13 (2006.01) Mutation or genetic engineering - Immunoglobulins

G01N 33/15 (2006.01) Investigating or analysing materials by specific methods not covered by groups - Medicinal preparations

G01N 33/53 (2006.01) Investigating or analysing materials by specific methods not covered by groups - Immunoassay

G01N 33/543 (2006.01) Investigating or analysing materials by specific methods not covered by groups - with an insoluble carrier for immobilising immunochemicals

G01N 33/567 (2006.01) Investigating or analysing materials by specific methods not covered by groups - utilising isolate of tissue or organ as binding agent