Owner Shire Laboratories, Inc.

Inventors Chang, Rong-Kun; BurnsideE, Beth; Guo, Xiaodi

Agent Spruson & Ferguson

Pub. Number AU-B-2002249881

PCT Pub. Number WO2002/058676

Priority 09/741,548 20.12.00 US

Filing date 20 December 2001

Wipo publication date 6 August 2002

Acceptance publication date 21 December 2006

A61K 9/22 (2006.01) Medicinal preparations characterised by special physical form - Sustained or differential release type

A61K 9/20 (2006.01) Medicinal preparations characterised by special physical form - Pills, lozenges or tablets

A61K 31/138 (2006.01) - Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine

A61K 31/155 (2006.01) - Amidines (), e.g. guanidine (HNC(NH)NH), isourea (HNC(OH)NH), isothiourea (HNC(SH)NH)

A61K 31/407 (2006.01) - condensed with heterocyclic ring systems, e.g. ketorolac, physostigmine

A61K 31/4168 (2006.01)

A61K 31/4375 (2006.01)

A61K 31/4402 (2006.01) - only substituted in position 2, e.g. pheniramine, bisacodyl

A61K 31/519 (2006.01) - ortho- or peri-condensed with heterocyclic rings

A61K 31/554 (2006.01) - having at least one nitrogen and at least one sulfur as ring hetero atoms, e.g. clothiapine, diltiazem

A61K 31/7048 (2006.01)

A61K 45/08 (2006.01) Medicinal preparations containing active ingredients not provided for in groups

A61K 47/02 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Inorganic compounds

A61K 47/10 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Alcohols

A61K 47/12 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Carboxylic acids

A61K 47/32 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds

A61K 47/34 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds

A61K 47/36 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Polysaccharides

A61K 47/38 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Cellulose

A61K 47/44 (2006.01) Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives - Oils, fats or waxes according to more than one of groups

A61P 7/00 (2006.01) Drugs for disorders of the blood or the extracellular fluid

A61P 25/28 (2006.01) Drugs for disorders of the nervous system

A61P 35/02 (2006.01) Antineoplastic agents