Owner BRISTOL-MYERS SQUIBB COMPANY

Inventors Todderud, C, Gordon.; Nelson, Thomas; Banas, Dana; Bol, David; Jackson, Donald, G.; Bassolino, Donna; Mintier, Gabe; Schieven, Gary; Feder, John; Finger, Joshua; Lee, Liana; Siemers, Nathan; Mcatee, Patrick; Krystek, Stanley; Suchard, Suzanne; Ramanathan, Chandra

Agent Phillips Ormonde Fitzpatrick

Pub. Number AU-A-2002249866

PCT Pub. Number WO2002/057460

Priority 60/256,868 20.12.00 US; 60/280,186 30.03.01 US; 60/287,735 01.05.01 US; 60/295,848 05.06.01 US; 60/300,465 25.06.01 US

Filing date 20 December 2001

Wipo publication date 30 July 2002

C12N 015/55 Mutation or genetic engineering - Hydrolases (3)

C12P 021/00 Preparation of peptides or proteins

A61K 038/46 Medicinal preparations containing peptides

C12Q 001/68 Measuring or testing processes involving enzymes or micro-organisms - involving nucleic acids

C12Q 001/42 Measuring or testing processes involving enzymes or micro-organisms - involving phosphatase

G06F 019/00 Digital computing or data processing equipment or methods, specially adapted for specific applications

G06F 017/50 Digital computing or data processing equipment or methods, specially adapted for specific functions - Computer-aided design

C12N 009/16 Enzymes, e.g. ligases (6.) - acting on ester bonds (3.1)

C12N 015/63 Mutation or genetic engineering - Introduction of foreign genetic material using vectors

C12N 005/10 Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

C07K 016/40 Immunoglobulins, e.g. monoclonal or polyclonal antibodies - against enzymes