Owner Regeneron Pharmaceuticals, Inc.

Inventors Murphy, Andrew J.; Yancopoulos, George D.

Agent Phillips Ormonde Fitzpatrick

Pub. Number AU-B-2002244023

PCT Pub. Number WO2002/066630

Priority 09/784,859 16.02.01 US

Filing date 15 February 2002

Wipo publication date 4 September 2002

Acceptance publication date 10 May 2007

A01K 67/027 (2006.01) Rearing or breeding animals, not otherwise provided for - New breeds of vertebrates

C07K 16/00 (2006.01) Immunoglobulins, e.g. monoclonal or polyclonal antibodies

C12N 1/15 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 1/19 (2006.01) Micro-organisms, e.g. protozoa - modified by introduction of foreign genetic material

C12N 5/02 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Propagation of single cells or cells in suspension

C12N 5/08 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines -

C12N 5/10 (2006.01) Undifferentiated human, animal or plant cells, e.g. cell lines - Cells modified by introduction of foreign genetic material, e.g. virus-transformed cells

C12N 15/09 (2006.01) Mutation or genetic engineering - Recombinant DNA-technology

C12N 15/90 (2006.01) Mutation or genetic engineering

C12P 21/02 (2006.01) Preparation of peptides or proteins - having a known sequence of two or more amino acids, e.g. glutathione

C12P 21/04 (2006.01) Preparation of peptides or proteins - Cyclic or bridged peptides or polypeptides, e.g. bacitracin

C12P 21/08 (2006.01) Preparation of peptides or proteins - Monoclonal antibodies

C12Q 1/02 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving viable micro-organisms

C12Q 1/68 (2006.01) Measuring or testing processes involving enzymes or micro-organisms - involving nucleic acids