Owner Merck Patent GmbH

Inventors Barnes, Christopher; Mederski, Werner; Tsaklakidis, Christos; Gleitz, Johannes; Dorsch, Dieter; Cezanne, Bertram

Agent Davies Collison Cave

Pub. Number AU-B-2002227993

PCT Pub. Number WO2002/057236

Priority 101 02 322.7 19.01.01 DE

Filing date 5 December 2001

Wipo publication date 30 July 2002

Acceptance publication date 9 August 2007

C07D 295/12 (2006.01) Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms

A61K 31/165 (2006.01) - having aromatic rings, e.g. colchicine, atenolol, progabide

A61K 31/167 (2006.01) - having the nitrogen atom of a carboxamide group directly attached to the aromatic ring, e.g. lidocaine, paracetamol

A61K 31/40 (2006.01) - having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil

A61K 31/402 (2006.01) - 1-aryl-substituted, e.g. piretanide

A61K 31/4166 (2006.01)

A61K 31/421 (2006.01) - 1,3-Oxazoles, e.g. pemoline, trimethadione

A61K 31/4245 (2006.01) - Oxadiazoles

A61K 31/439 (2006.01) - the ring forming part of a bridged ring system, e.g. quinuclidine

A61K 31/4412 (2006.01) - having oxo groups directly attached to the heterocyclic ring

A61K 31/45 (2006.01) - having oxo groups directly attached to the heterocyclic ring, e.g. cycloheximide

A61K 31/454 (2006.01)

A61K 31/4545 (2006.01)

A61K 31/495 (2006.01) - having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine

A61K 31/4965 (2006.01) - Non-condensed pyrazines

A61K 31/50 (2006.01) - Pyridazines

A61K 31/5375 (2006.01) - 1,4-Oxazines, e.g. morpholine

A61K 31/545 (2006.01) - Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula , e.g. cephalosporins, cefaclor, cephalexine

A61K 31/55 (2006.01) - having seven-membered rings, e.g. azelastine, pentylenetetrazole

A61P 7/02 (2006.01) Drugs for disorders of the blood or the extracellular fluid

A61P 9/10 (2006.01) Drugs for disorders of the cardiovascular system

A61P 29/00 (2006.01) Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents

A61P 35/00 (2006.01) Antineoplastic agents